2018 - A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

plos one 2018

Authors: Kesia Esther da Silva, Wirlaine Glauce Maciel, Julio Croda, Rodrigo Cayô, Ana Carolina Ramos, Romário Oliveira de Sales, Mariana Neri Lucas Kurihara, Nathalie Gaebler Vasconcelos, Ana Cristina Gales, Simone Simionatto.

Abstract 

The global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) strains has restricted the therapeutic options available to treat infections due to this pathogen. Understanding the prevalence of such infections and the underlying genetic mechanisms of resistance may help in the implementation of adequate measures to control and prevent acquisition of nosocomial infections, especially in an intensive care unit setting. This study describes the molecular characteristics and risk factors associated with OXA-23-producing A. baumannii infections. A case-control study was undertaken from September/2013 to April/2015. Acquisition of OXA-23-producing A. baumannii was found to be associated with the use of nasogastric tubes, haemodialysis, and the use of cephalosporins. These isolates were only susceptible to amikacin, gentamicin, tigecycline, and colistin, and contained the ISAba1 insertion sequence upstream ofblaOXA-23 and blaOXA-51 genes. Twenty-six OXA-23-producing A. baumannii strains belonged to the ST79 (CC79) clonal group,and patients infected or colonised by these isolates had a higher mortality rate (34.6%). In conclusion, this study showed a dissemination of OXA-23-producing A. baumannii strains that was associated with several healthcare-related risk factors and high mortality rates among intensive care unit patients.

DOI: https://doi.org/10.1371/journal.pone.0209367

 

Artigos Relacionados - Artigos Científicos

06 Jun 2021 02:00

Authors: Tuanny Teixeira Pinheiro, Flávio Geraldo Rezende de Freitas, Karla Tuanny Fiorese [ ... ]

Artigos Cientificos em Destaque
07 Jun 2021 02:00

Authors: Rodrigo Yokota, Fernanda Aparecida Ronchi, Fernanda Barrinha Fernandes, Zaira Palomino Jara, [ ... ]

Artigos Cientificos em Destaque
08 Jun 2021 04:00

Authors: Fiorese Coimbra, Karla Tuanny MD; de Freitas, Flávio Geraldo Rezende MD, PhD; Bafi, [ ... ]

Artigos Cientificos em Destaque

© 2013 - 2022 Universidade Federal de São Paulo - Unifesp

Rua Botucatu, 740, 5º andar, sala 562, Edifício Octávio de Carvalho - Vila Clementino • CEP 04023-062 - São Paulo - SP 

+55 11 3385-4100 Ramal 3027 / +55 11 5576-4228 • ppg.medicinatranslacional@unifesp.br