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Bruno Moreira Silva

Currículo Lattes

E-mail: silva.bruno@unifesp.br

Selecione a Área ou Linha de Pesquisa para descrição.

Área: FISIOLOGIA HUMANA/ANIMAL E DO EXERCÍCIO APLICADA OU NÃO AO ESPORTE

Nesta área de concentração, busca-se investigar a modulação dos sistemas cardiorrespiratório, metabólico e muscular durante o exercício físico buscando compreender os mecanismos fisiológicos e fisiopatológicos envolvidos. A investigação ainda abrangeria compreender o papel benéfico do exercício nas doenças cardiorrespiratórias e metabólicas entre outras.

Linha de Pesquisa: FISIOLOGIA HUMANA E/OU ANIMAL INTEGRATIVA

Investigar a regulação integrativa dos sistemas cardiorrespiratório e muscular durante o exercício físico, em humanos saudáveis ou com doenças cardiorrespiratórias e/ou metabólicas, com o intuito de compreender mecanismos fisiológicos e fisiopatológicos e de promover aumento da capacidade para realizar exercícios físicos. A partir de projetos iniciados em 2014, nos próximos anos pretende-se investigar:

1) Mecanismos e aplicações de uma manobra conhecida como pré-condicionamento isquêmico (PCI), no âmbito da fisiologia do exercício aplicada ao esporte (Projeto de pesquisa vinculado: Efeito do Pré-Condicionamento Isquêmico de Músculos Estriados Esqueléticos sobre Respostas Metabólicas ao Exercício Físico em Humanos);  2) Contribuição do quimiorreflexo periférico para o controle de respostas neurocardiovasculares ao exercício físico e no período da recuperação pós-exercício em humanos saudáveis e em pacientes com insuficiência cardíaca (Projeto de pesquisa vinculado: Contribuição Tônica do Quimiorreflexo Periférico no Controle Vagal do Coração em Repouso e na Recuperação do Exercício em Pacientes com Insuficiência Cardíaca Crônica).



Orientações em Andamento:

Data de Matrícula Aluno Programa de Pós-Graduação Nível
01/02/2023 THIAGO RIBEIRO LOPES Medicina Translacional (33009015069P4) PÓS-DOUTORADO
01/12/2022 ADRIANO DE ALMEIDA PEREIRA Medicina Translacional (33009015069P4) PÓS-DOUTORADO
01/08/2022 IVONE LIMA BONIFÁCIO Medicina (Pneumologia) (33009015020P5) MESTRADO
01/08/2022 JOÃO PAULO FINOTTI FONSECA Medicina (Pneumologia) (33009015020P5) MESTRADO
01/08/2022 MARIA CLARA RODRIGUES DE GÓES DA TRINDADE Medicina (Pneumologia) (33009015020P5) DOUTORADO
01/05/2022 FELIPE SILVA GOMES Medicina Translacional (33009015069P4) DOUTORADO
01/06/2019 DIOGO MACHADO DE OLIVEIRA Medicina Translacional (33009015069P4) DOUTORADO

Orientações Concluídas:

Data de Titulação Aluno Programa de Pós-Graduação Nível
01/07/2021 THIAGO RIBEIRO LOPES Medicina Translacional (33009015069P4) DOUTORADO
28/01/2021 TAMIRES DA SILVA CESAR Medicina (Pneumologia) (33009015020P5) MESTRADO
29/10/2020 LILIANE CUNHA ARANDA Medicina (Pneumologia) (33009015020P5) DOUTORADO
30/07/2020 TIAGO OBEID DE FREITAS Medicina (Pneumologia) (33009015020P5) MESTRADO
30/04/2020 INDYANARA CRISTINA RIBEIRO Medicina (Pneumologia) (33009015020P5) MESTRADO
25/10/2019 ANA LUIZA CARRARI SAYEGH Medicina (Pneumologia) (33009015020P5) PÓS-DOUTORADO
30/05/2019 DIOGO MACHADO DE OLIVEIRA Medicina Translacional (33009015069P4) MESTRADO
28/11/2018 MARCELLE DE PAULA RIBEIRO Medicina Translacional (33009015069P4) DOUTORADO
29/03/2018 TALITA MIRANDA SILVA Medicina (Pneumologia) (33009015020P5) MESTRADO
30/08/2016 JEANN LÚCCAS DE CASTRO SABINO DE CARVALHO Medicina Translacional (33009015069P4) MESTRADO
05/04/2016 THIAGO HENRIQUE NUNES FERREIRA Medicina Translacional (33009015069P4) MESTRADO
30/09/2014 THIAGO DOS SANTOS ROSA Medicina Translacional (33009015069P4) DOUTORADO

Artigos Completos Publicados em Periódicos Científicos:

  1. RODRIGUES, P. T. V. ; CORREA, L. A. ; PAULA-RIBEIRO, M. ; SILVA, B. M. ; REIS, F. J. J. ; NOGUEIRA, L. A. C.. Patients with impaired descending nociceptive inhibitory system present altered cardiac vagal control at rest. Pain Physician. v. Pain Physician, p. E409-E418, 2018.
  2. SILVA, T. M. ; ARANDA, L. C. ; PAULA-RIBEIRO, M. ; OLIVEIRA, D. M. ; MEDEIROS, W. M. ; VIANNA, L. C. ; NERY, L. E. ; SILVA, B. M.. Hyperadditive ventilatory response arising from interaction between the carotid chemoreflex and the muscle mechanoreflex in healthy humans. JOURNAL OF APPLIED PHYSIOLOGY. v. JOURNAL OF APPLIED PHYSIOLOGY, p. 215-225, 2018. http://dx.doi.org/10.1152/japplphysiol.00009.2018
  3. VIANNA, LAURO C. ; FERNANDES, IGOR A. ; MARTINEZ, DANIEL G. ; TEIXEIRA, ANDRÉ L. ; Silva, Bruno M. ; FADEL, PAUL J. ; NÓBREGA, ANTONIO C. L.. Water drinking enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in healthy young humans. EXPERIMENTAL PHYSIOLOGY. v. EXPERIMENTAL PHYSIOLOGY, p. 1318-1325, 2018. http://dx.doi.org/10.1113/ep087095
  4. LOPES, T. R. ; SABINO-CARVALHO, J. L. C. ; FERREIRA, T. N. ; SUCCI, J. E. ; SILVA, A. C. ; SILVA, B. M.. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. Frontiers in Physiology. v. Frontiers in Physiology, p. 1465, 2018. http://dx.doi.org/10.3389/fphys.2018.01465
  5. SABINO-CARVALHO, J. L. C. ; LOPES, T. R. ; OBEID-FREITAS, T. ; FERREIRA, T. N. ; SUCCI, J. E. ; SILVA, A. C. ; SILVA, B. M.. Effect of Ischemic Preconditioning on Endurance Performance Does Not Surpass Placebo. Medicine and Science in Sports and Exercise. v. Medicine and Science in Sports and Exercise, p. 124-132, 2017. http://dx.doi.org/10.1249/mss.0000000000001088
  6. MACHADO, A. C. ; BARBOSA, T. C. ; SALES, A. R. K. ; SOUZA, M. N. ; NOBREGA, A. C. L. ; SILVA, B. M.. Adults with initial metabolic syndrome have altered muscle deoxygenation during incremental exercise. Obesity (Silver Spring, Md.). v. Obesity (Silver Spring, Md.), p. 424-431, 2017. http://dx.doi.org/10.1002/oby.21744
  7. SILVA, B. M.; LOPES, T. R. ; VIANNA, L. C.. Commentary on viewpoint: could small-diameter muscle afferents be responsible for the ergogenic effect of limb ischemic preconditioning?. Journal of Applied Physiology (1985). v. Journal of Applied Physiology (1985), p. 723-724, 2017.
  8. SABINO-CARVALHO, J. L. C. ; FERREIRA, T. N. ; LOPES, T. R. ; SILVA, B. M.. Response to: Crucial points for analysis of ischemic preconditioning in sports and exercise. Medicine and Science in Sports and Exercise. v. Medicine and Science in Sports and Exercise, p. 1497, 2017.
  9. LOPES, T. R. ; ALMEIDA, A. A. ; SILVA, A. C. ; SILVA, B. M.. Are heart rate deflection point and peak velocity determined in the Université of Montréal Track Test valid to approximate aerobic parameters measured in the laboratory?. Journal of Sports Medicine and Physical Fitness (Testo stampato). v. Journal of Sports Medicine and Physical Fitness (Testo stampato), p. 510-519, 2016.
  10. NAKAMOTO, F. P. ; IVAMOTO, R. ; ANDRADE, M. S. ; LIRA, C. ; SILVA, B. M. ; SILVA, A. C.. Effect of intermittent hypoxic training followed by intermittent hypoxic exposure on aerobic capacity of long distance runners. Journal of Strength and Conditioning Research. v. Journal of Strength and Conditioning Research, p. 1708-1720, 2016.
  11. ROSA, T. S. ; SIMOES, H. G. ; ROGERO, M. M. ; MORAES, M. R. ; DENADAI, B. S. ; ARIDA, R. M. ; ANDRADE, M. S. ; SILVA, B. M.. Severe obesity shifts metabolic thresholds but does not attenuate aerobic training adaptations in zucker rats. Frontiers in Physiology. v. Frontiers in Physiology, p. 122, 2016. http://dx.doi.org/10.3389/fphys.2016.00122
  12. FERREIRA, T. N. ; CARVALHO, J. L. C. S. ; LOPES, T. R. ; RIBEIRO, I. C. ; SUCCI, J. E. ; SILVA, A. C. ; SILVA, B. M.. Ischemic Preconditioning and Repeated Sprint Swimming. Medicine and Science in Sports and Exercise. v. Medicine and Science in Sports and Exercise, p. 1967-1975, 2016. http://dx.doi.org/10.1249/MSS.0000000000000977
  13. BARBOSA, T. C. ; MACHADO, A. C. ; BRAZ, I. D. ; FERNANDES, I. A. ; VIANNA, L. C. ; NÓBREGA, A. C. L. ; SILVA, B. M.. Remote ischemic preconditioning delays fatigue development during handgrip exercise. Scandinavian Journal of Medicine e Science in Sports. v. Scandinavian Journal of Medicine e Science in Sports, p. 356-364, 2015. http://dx.doi.org/10.1111/sms.12229
  14. ROCHA, N. G. ; SALES, A. R. K. ; PENEDO, L. A. ; PEREIRA, F. S. ; SILVA, M. S. ; MIRANDA, R. L. ; SILVA, J. F. R. ; SILVA, B. M. ; SANTOS, A. A. ; NÓBREGA, A. C. L.. Impaired circulating angiogenic cells mobilization and metalloproteinase-9 activity after dynamic exercise in early metabolic syndrome. BIOMED RES INT. v. BIOMED RES INT, p. 920356, 2015. http://dx.doi.org/10.1155/2015/920356
  15. SABINO-CARVALHO, J. L. C. ; BARBOSA, T. C. ; SILVA, B. M.. Letter to the editor: What is the effect of ischemic preconditioning on the kinetics of pulmonary oxygen uptake and muscle deoxygenation during exercise?. PHYSIOLOGICAL REPORTS. v. PHYSIOLOGICAL REPORTS, p. e12540-e12540, 2015.
  16. ROCHA, NATALIA G. ; SALES, ALLAN R.K. ; MIRANDA, RENAN L. ; SILVA, MAYRA S. ; SILVA, JEMIMA F.R. ; Silva, Bruno M. ; SANTOS, ALINE A. ; NÓBREGA, ANTONIO C.L.. Aerobic exercise modulation of mental stress-induced responses in cultured endothelial progenitor cells from healthy and metabolic syndrome subjects. Life Sciences (1973). v. Life Sciences (1973), p. 93-99, 2015. http://dx.doi.org/10.1016/j.lfs.2014.12.026
  17. VIANNA, LAURO C. ; Silva, Bruno M. ; NÓBREGA, ANTONIO CLAUDIO L.. Sex differences in blood pressure responses to mental stress are abolished after a single bout of exercise: underlying hemodynamic mechanisms. Journal of Physiological Sciences. v. Journal of Physiological Sciences, p. 213-219, 2014. http://dx.doi.org/10.1007/s12576-014-0306-y
  18. NÓBREGA, A. C. ; O'LEARY, D. S. ; SILVA, B. M. ; MAROUNGIU, E. ; PIEPOLLI, M. F. ; CRISAFULLI, A.. Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents. Journal of Biomedicine and Biotechnology (Print). v. Journal of Biomedicine and Biotechnology (Print), p. 1-20, 2014. http://dx.doi.org/10.1155/2014/478965
  19. SALES, A. R. K. ; FERNANDES, I. A. ; ROCHA, N. G. ; COSTA, L. S. ; ROCHA, H. M. ; MATTOS, J. D. ; VIANNA, LAURO C. ; SILVA, B. M. ; NÓBREGA, A. C.. Aerobic exercise acutely prevents the endothelial dysfunction induced by mental stress among subjects with metabolic syndrome: the role of shear rate. American Journal of Physiology. Heart and Circulatory Physiology. v. American Journal of Physiology. Heart and Circulatory Physiology, p. H963-H971, 2014. http://dx.doi.org/10.1152/ajpheart.00811.2013
  20. FERNANDES, I. A. ; SALES, A. R. K. ; ROCHA, N. G. ; SILVA, B. M. ; VIANNA, L. C. ; NÓBREGA, A. C.. Preserved flow-mediated dilation but delayed time-to-peak diameter in individuals with metabolic syndrome. Clinical Physiology and Functional Imaging (Print). v. Clinical Physiology and Functional Imaging (Print), p. 270-276, 2014.
  21. HIRAI, D. M. ; ROSEGUINI, B. T. ; SILVA, B. M.. Skeletal muscle functional hyperemia: ROS generation and redundant mechanisms. Journal of Applied Physiology (1985). v. Journal of Applied Physiology (1985), p. 706-706, 2014.
  22. ROSEGUINI, B. T. ; HIRAI, D. M. ; ALENCAR, M. C. ; RAMOS, R. P. ; SILVA, B. M. ; WOLOSKER, N. ; NEDER, J. A. ; NERY, L. E.. Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. v. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, p. R396-R404, 2014. http://dx.doi.org/10.1152/ajpregu.00183.2014
  23. MORENO, A. M. ; CASTRO, R. R. T. ; SILVA, B. M. ; GUERRA, M. P. M. ; REZENDE, A. ; SANTANA JUNIOR, M. ; NOBREGA, A. C. L.. Intercostal and forearm muscles deoxygenation during respiratory fatigue in patients with heart failure: potential role of a respiratory muscle metaboreflex. Brazilian Journal of Medical and Biological Research (Impresso). v. Brazilian Journal of Medical and Biological Research (Impresso), p. 972-976, 2014.
  24. SILVA, B. M.; BARBOSA, T. C. ; NEVES, F. J. ; SALES, A. R. K. ; ROCHA, N. G. ; MEDEIROS, R. F. ; PEREIRA, F. S. ; GARCIA, V. P. ; CARDOSO, F. T. ; NOBREGA, A. C. L.. eNOS gene haplotype is indirectly associated with the recovery of cardiovascular autonomic modulation from exercise. Autonomic Neuroscience: Basic e Clinical. v. Autonomic Neuroscience: Basic e Clinical, p. 77-84, 2014.
  25. SILVA, B. M.; NEVES, F. J. ; ROCHA, N. G. ; SALES, A. R. K. ; MEDEIROS, R. F. ; BARBOSA, T. C. ; PEREIRA, F. S. ; CARDOSO, F. T. ; NÓBREGA, A. C. L.. Endothelial nitric oxide gene haplotype reduces the effect of a single bout of exercise on the vascular reactivity in healthy subjects. Translational Research: the journal of laboratory and clinical medicine. v. Translational Research: the journal of laboratory and clinical medicine, p. 15-25, 2013.
  26. LOPEZ, M. G. ; SILVA, B. M. ; JOYNER, M. J. ; CASEY, D. P.. Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails. European Journal of Applied Physiology (Print). v. European Journal of Applied Physiology (Print), p. 1449-1456, 2013. http://dx.doi.org/10.1007/s00421-012-2570-y
  27. LOPEZ, M. G. ; SILVA, B. M. ; JOYNER, M. J. ; CASEY, D. P.. Ischemic exercise hyperemia in the human forearm is reproducible but adenosine and nitric oxide are not obligatory. European Journal of Applied Physiology (Print). v. European Journal of Applied Physiology (Print), p. 2065-2072, 2012.
  28. SALES, A. R. K. ; SILVA, B. M. ; NEVES, F. J. ; ROCHA, N. G. ; MEDEIROS, R. F. ; CASTRO, R. R. T. ; NÓBREGA, A. C. L.. Diet and exercise training reduce blood pressure and improve autonomic modulation in women with prehypertension. European Journal of Applied Physiology (Print). v. European Journal of Applied Physiology (Print), p. 3369-3378, 2012.
  29. NEVES, F. J. ; CARVALHO, A. C. ; ROCHA, N. G. ; SILVA, B. M. ; SALES, A. R. K. ; CASTRO, R. R. T. ; ROCHA, J. D. ; THOMAZ, T. G. ; NÓBREGA, A. C. L.. Hemodynamic mechanisms of the attenuated blood pressure response to mental stress after a single bout of maximal dynamic exercise in healthy subjects. Brazilian Journal of Medical and Biological Research (Impresso). v. Brazilian Journal of Medical and Biological Research (Impresso), p. 610-616, 2012.
  30. SILVA, B. M.; FERNANDES, I. A. ; VIANNA, L. C.. Welcome the carotid chemoreflex to the ?neural control of the circulation during exercise? club. Journal of Physiology (London. Print). v. Journal of Physiology (London. Print), p. 2835-2836, 2012.
  31. PAIVA, V. C. ; Santana, KR ; SILVA, B. M. ; RAMOS, P. S. ; Lovisi, JC ; ARAÚJO, C. G. S. ; RICARDO, Djalma Rabelo. Comparação entre métodos de avaliação da modulação vagal - resposta do autor. Arquivos Brasileiros de Cardiologia (Impresso). v. Arquivos Brasileiros de Cardiologia (Impresso), p. 570, 2012.
  32. SILVA, B. M.; NEVES, F. J. ; NEGRÃO, M. V. ; ALVES, C. R. ; DIAS, R. G. ; ALVES, G. B. ; PEREIRA, A. C. ; RONDON, M. U. ; KRIEGER, J. E. ; NEGRÃO, C. E. ; NÓBREGA, A. C. L.. eNOSPolymorphisms and Adaptation of Parasympathetic Modulation to Exercise Training. Medicine and Science in Sports and Exercise. v. Medicine and Science in Sports and Exercise, p. 1611-1618, 2011.
  33. ROCHA, N. G. ; NEVES, F. J. ; SILVA, B. M. ; SALES, A. R. K. ; NÓBREGA, A. C. L.. The 894G>T endothelial nitric oxide synthase genetic polymorphism affects hemodynamic responses to mental stress performed before and after exercise. European Journal of Applied Physiology (Print). v. European Journal of Applied Physiology (Print), p. 877-886, 2011. http://dx.doi.org/10.1007/s00421-011-2042-9
  34. PAIVA, V. C. ; SANTANA, K. R. ; RAMOS, P. S. ; SILVA, B. M. ; RICARDO, D. R.. Comparaçao entre métodos de avaliaçao da modulação vagal cardíaca. Arquivos Brasileiros de Cardiologia (Impresso). v. Arquivos Brasileiros de Cardiologia (Impresso), p. 493-501, 2011.
  35. MEDEIROS, R. F. ; SILVA, B. M. ; NEVES, F. J. ; ROCHA, N. G. ; SALES, A. R. K. ; NÓBREGA, A. C. L.. Impaired hemodynamic response to mental stress in subjects with prehypertension is improved after a single bout of maximal dynamic exercise. Clinics (USP. Impresso). v. Clinics (USP. Impresso), p. 1523-1529, 2011. http://dx.doi.org/10.1590/S1807-59322011000900003
  36. SABINO, P. G. ; SILVA, B. M. ; BRUNETTO, A. F.. Nutritional state is related to fat free mass, exercise capacity and inspiratory strength in severe COPD patients. Clinics (USP. Impresso). v. Clinics (USP. Impresso), p. 599-605, 2010.
  37. BARNES, J. N. ; SILVA, B. M.. Ascent to altitude: an integrated cerebrovascular, ventilatory and acid-base response. Journal of Physiology (London. Print). v. Journal of Physiology (London. Print), p. 1815-1816, 2010. http://dx.doi.org/10.1113/jphysiol.2010.189837
  38. RICARDO, D. R. ; SILVA, B. M. ; VIANNA, L. C. ; ARAÚJO, C. G. S.. Cardiac vagal withdrawal and reactivation during repeated rest exercise transitions. European Journal of Applied Physiology (Print). v. European Journal of Applied Physiology (Print), p. 933-942, 2010. http://dx.doi.org/10.1007/s00421-010-1555-y
  39. BARRETO, J. L. W. ; SILVA, B. M. ; SILVA, L. E. ; NÓBREGA, A. C. L. ; THOMAZ, T. G.. Fluxo nas carótidas e artérias vertebrais extracranianas em pacientes com morte cerebral. Revista Brasileira de Cardiologia. v. Revista Brasileira de Cardiologia, p. 57-67, 2010.
  40. NEVES, FABRICIA J ; Silva, Bruno M ; ROCHA, NATÁLIA G ; SALES, ALLAN RK ; RIBEIRO, GEORGINA S ; NÓBREGA, ANTONIO C. Effect of the 894G>T polymorphism of the endothelial nitric oxide synthase on vascular reactivity following maximal dynamic exercise. Journal of Hypertension. v. Journal of Hypertension, p. 764-770, 2010. http://dx.doi.org/10.1097/hjh.0b013e328334f55c

Orientadores
Visto: 534

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